Cardinals vs Bills Picks & Predictions for Week 1: Cooked Birds

The new-look Buffalo Bills are a team to watch on Sunday as they kick off the NFL season against the retooling but dangerous Arizona Cardinals.

After overhauling their receiving corps, two things remain the same, and my Cardinals vs Bills predictions are bullish on one particular Bills player. 

Find out why James Cook is my focus in my NFL picks for Sunday, September 8. 

Cardinals vs Bills prediction

My best betJames Cook Over 82.5 rushing + receiving yards (-118 at BetMGM)

My analysisJump onboard the James Cook hype train with me here as the Buffalo Bills offense walks into a favorable Week 1 matchup against an Arizona Cardinals defense that ranked last in DVOA in 2023.

It’s no secret that Cook was o…